View source for 9kff


==Truncated Fzo1 with modified LD,transition-like state==
<StructureSection load='9kff' size='340' side='right'caption='[[9kff]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kff]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KFF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kff OCA], [https://pdbe.org/9kff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kff RCSB], [https://www.ebi.ac.uk/pdbsum/9kff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kff ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FZO1_YEAST FZO1_YEAST] Essential transmembrane GTPase, which mediates mitochondrial fusion (PubMed:10562274, PubMed:11266460, PubMed:15297626, PubMed:15760898, PubMed:16624808, PubMed:19812251, PubMed:21385840, PubMed:21502136, PubMed:23317502, PubMed:27253069, PubMed:9685359, PubMed:9786948). Fusion proceeds through several steps; first mitochondria are tethered together, then brought into close contact, followed by the formation of a docking ring around contact areas, and finally membrane fusion (PubMed:27253069). Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondrial morphology, which is balanced between fusion and fission, mediated by FZO1 and DNM1, respectively (PubMed:10562274). Functions antagonistically with DNM1 (PubMed:10562274). Probably acts by forming membrane contact sites that mediate mitochondrial membrane fusion (PubMed:27253069). Mitochondrial docking and fusion requires GTP hydrolysis (PubMed:15297626, PubMed:19812251, PubMed:27253069). Mitochondrial fusion also promotes increased lifespan.<ref>PMID:10562274</ref> <ref>PMID:11266460</ref> <ref>PMID:15297626</ref> <ref>PMID:15760898</ref> <ref>PMID:19812251</ref> <ref>PMID:20505073</ref> <ref>PMID:20550520</ref> <ref>PMID:21385840</ref> <ref>PMID:22353369</ref> <ref>PMID:27253069</ref> <ref>PMID:9685359</ref> <ref>PMID:9786948</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Gao S]]
[[Category: Huang S-J]]