View source for 9ytz


==Structure of Ovine gammaherpesvirus 2 ORF73 LANA bound to importin alpha 2==
<StructureSection load='9ytz' size='340' side='right'caption='[[9ytz]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ytz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Ovine_gammaherpesvirus_2 Ovine gammaherpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YTZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ytz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ytz OCA], [https://pdbe.org/9ytz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ytz RCSB], [https://www.ebi.ac.uk/pdbsum/9ytz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ytz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ovine gammaherpesvirus 2]]
[[Category: Forwood JK]]
[[Category: Nath B]]