View source for 1xy4


==NMR strcutre of sst1-selective somatostatin (SRIF) analog 1==
<StructureSection load='1xy4' size='340' side='right'caption='[[1xy4]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1xy4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=IAM:4-[(ISOPROPYLAMINO)METHYL]PHENYLALANINE'>IAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy4 OCA], [https://pdbe.org/1xy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy4 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy4 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional NMR structures of six analogues of somatostatin (SRIF) are described. These analogues with the amino acid 4-(N-isopropyl)-aminomethylphenylalanine (IAmp) at position 9 exhibit potent and highly selective binding to human SRIF subtype 1 receptors (sst(1)). The conformations reveal that the backbones of these analogues have a hairpin-like structure similar to the sst(2)-subtype-selective analogues. This structure serves as a scaffold for retaining a unique arrangement of the side chains of d-Trp(8), IAmp(9), Phe(7), and Phe(11) or m-I-Tyr(11) (m-I-Tyr = mono-iodo-tyrosine). The conformational preferences and results from biological analyses of these analogues(1,2) allow a detailed study of the structure-activity relationship of SRIF. The proposed consensus pharmacophore of the sst(1)-selective analogues requires a unique set of distances between an indole/2-naphthyl ring, an IAmp side chain, and two aromatic rings. This motif is necessary and sufficient to explain the binding affinities of all of the analogues studied and is distinct from the existing models suggested for sst(4) as well as sst(2)/sst(5) selectivity.

Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.,Grace CR, Durrer L, Koerber SC, Erchegyi J, Reubi JC, Rivier JE, Riek R J Med Chem. 2005 Jan 27;48(2):523-33. PMID:15658866<ref>PMID:15658866</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1xy4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Durrer L]]
[[Category: Erchegyi J]]
[[Category: Grace CRR]]
[[Category: Koerber SC]]
[[Category: Reubi JC]]
[[Category: Riek R]]
[[Category: Rivier JE]]