View source for 26kd


==Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in the apo2 state from the 5'/3' vRNA dual-promoter dataset==
<StructureSection load='26kd' size='340' side='right'caption='[[26kd]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[26kd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthonairovirus_haemorrhagiae Orthonairovirus haemorrhagiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=26KD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=26KD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=26kd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=26kd OCA], [https://pdbe.org/26kd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=26kd RCSB], [https://www.ebi.ac.uk/pdbsum/26kd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=26kd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/L_CCHFI L_CCHFI] Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Orthonairovirus haemorrhagiae]]
[[Category: Liang Z]]
[[Category: Liu X]]
[[Category: Ma J]]
[[Category: Wu H]]
[[Category: Yang K]]