View source for 2akh


==Normal mode-based flexible fitted coordinates of a non-translocating SecYEG protein-conducting channel into the cryo-EM map of a SecYEG-nascent chain-70S ribosome complex from E. coli==
<SX load='2akh' size='340' side='right' viewer='molstar' caption='[[2akh]], [[Resolution|resolution]] 14.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2akh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AKH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 14.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2akh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2akh OCA], [https://pdbe.org/2akh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2akh RCSB], [https://www.ebi.ac.uk/pdbsum/2akh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2akh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SECG_ECOLI SECG_ECOLI] Subunit of the protein translocation channel SecYEG. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true it also results in FtsH-mediated degradation of SecY. Treatment with antibiotics that block translation elongation such as chloramphenicol also leads to degradation of SecY and SecE but not SecG.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/2akh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2akh ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
__TOC__
</SX>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Ban N]]
[[Category: Brooks III CL]]
[[Category: Frank J]]
[[Category: Jenni S]]
[[Category: Mitra KM]]
[[Category: Schaffitzel C]]
[[Category: Shaikh T]]
[[Category: Tama F]]