View source for 2mxv


==NMR structure of the first Zinc Finger domain of RBM10==
<StructureSection load='2mxv' size='340' side='right'caption='[[2mxv]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MXV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mxv OCA], [https://pdbe.org/2mxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mxv RCSB], [https://www.ebi.ac.uk/pdbsum/2mxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mxv ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RBM10_HUMAN RBM10_HUMAN] TARP syndrome. TARP syndrome (TARPS) [MIM:[https://omim.org/entry/311900 311900]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:20451169</ref> 
== Function ==
[https://www.uniprot.org/uniprot/RBM10_HUMAN RBM10_HUMAN] May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).<ref>PMID:18315527</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Geralt M]]
[[Category: Serrano P]]
[[Category: Wuthrich K]]