View source for 2wj8


==Respiratory Syncitial Virus RiboNucleoProtein==
<StructureSection load='2wj8' size='340' side='right'caption='[[2wj8]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2wj8]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)] and [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A_strain_Long Human respiratory syncytial virus A strain Long]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJ8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO4:BORATE+ION'>BO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj8 OCA], [https://pdbe.org/2wj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wj8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NCAP_HRSVA NCAP_HRSVA] Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases.<ref>PMID:9299631</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wj8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wj8 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Laminin|Laminin]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human respiratory syncytial virus A strain Long]]
[[Category: Large Structures]]
[[Category: Bedouelle H]]
[[Category: Bhella D]]
[[Category: Bricogne G]]
[[Category: Castagne N]]
[[Category: Damier-Piolle L]]
[[Category: Duquerroy S]]
[[Category: Eleouet J]]
[[Category: MacLellan K]]
[[Category: Rey FA]]
[[Category: Tawar RG]]
[[Category: Varela PF]]
[[Category: Vonrhein C]]