View source for 3php


==STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING==
<StructureSection load='3php' size='340' side='right'caption='[[3php]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3php]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PHP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3php FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3php OCA], [https://pdbe.org/3php PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3php RCSB], [https://www.ebi.ac.uk/pdbsum/3php PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3php ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The solution structure of an RNA-hairpin present in the pseudoknot, which is found at the 3'-terminus of turnip yellow mosaic virus genomic RNA, has been solved by nuclear magnetic resonance spectroscopy. The loop, which contains the sequence 5'-GGGUCA-3', was found to be highly structured and, contrary to expectations, does not attain its stability through GA or GC base pair formation but by triple interactions between the tilted adenosine and the minor groove sides of the first two guanosines. Interestingly, a very similar conformation was found for the cognate pseudoknot, implying that the 3'-hairpin is preformed for folding into a pseudoknotted structure. These findings suggest a mechanism of 'predetermined-fit' as a principle in RNA folding.

Structure of the 3'-hairpin of the TYMV pseudoknot: preformation in RNA folding.,Kolk MH, van der Graaf M, Fransen CT, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW EMBO J. 1998 Dec 15;17(24):7498-504. PMID:9857204<ref>PMID:9857204</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3php" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Heus HA]]
[[Category: Hilbers CW]]
[[Category: Kolk MH]]
[[Category: Pleij CWA]]
[[Category: Van Der Graaf M]]
[[Category: Wijmenga SS]]