View source for 3tvq


==Crystal structure of TCM Aro/Cyc complexed with trans-dihidroquercetin==
<StructureSection load='3tvq' size='340' side='right'caption='[[3tvq]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tvq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_glaucescens Streptomyces glaucescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TVQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DQH:(2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE'>DQH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tvq OCA], [https://pdbe.org/3tvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tvq RCSB], [https://www.ebi.ac.uk/pdbsum/3tvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tvq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TCMN_STRGA TCMN_STRGA] The N-terminal domain enhances the formation of an early, partially cyclized intermediate, while the C-terminal domain catalyzes the 3-O-methylation of one or more later intermediates in the biosynthetic pathway. Catalyzes the methylation of tetracenomycin D3 (Tcm D3) to yield Tcm B3. Catalyzes as well the following side reactions: methylation of 8-O-methyl-Tcm D3 to yield Tcm E; and of 9-carboxymethyl-Tcm B3 to yield Tcm A2.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces glaucescens]]
[[Category: Ames BD]]
[[Category: Lee M-Y]]
[[Category: Tsai S-C]]