View source for 3typ


==The crystal structure of the inorganic triphosphatase NE1496==
<StructureSection load='3typ' size='340' side='right'caption='[[3typ]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3typ]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TYP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3typ FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3typ OCA], [https://pdbe.org/3typ PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3typ RCSB], [https://www.ebi.ac.uk/pdbsum/3typ PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3typ ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/3PASE_NITEU 3PASE_NITEU] Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi). The enzyme has a strong preference for linear PPPi compared with cyclic PPPi (cyclic trimetaphosphate) and to the linear P4. The longer chains polyphosphate are not hydrolyzed. It has only a slight thiamine triphosphatase (ThTPase) activity. Nucleoside triphosphatase activity is negligible in the presence of magnesium, but a small activity is observed in the presence of manganese, in particular with GTP.<ref>PMID:21840996</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Nitrosomonas europaea]]
[[Category: Binkowski TA]]
[[Category: Edwards AM]]
[[Category: Joachimiak A]]
[[Category: Lunin VV]]
[[Category: Onopriyenko O]]
[[Category: Savchenko A]]
[[Category: Skarina T]]