View source for 4p17


==Crystal structure of the Chlamydomonas flagellar RabGAP TBC domain.==
<StructureSection load='4p17' size='340' side='right'caption='[[4p17]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4p17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P17 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7941&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p17 OCA], [https://pdbe.org/4p17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p17 RCSB], [https://www.ebi.ac.uk/pdbsum/4p17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p17 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Rab GTPases play a crucial role in the regulation of many intracellular membrane trafficking pathways including endocytosis and ciliogenesis. Rab GTPase activating proteins (RabGAPs) increase the GTP hydrolysis rate of Rab GTPases and turn them into guanine nucleotide diphosphate (GDP) bound inactive form. Here, we determined the crystal structure of the putative catalytic domain of a RabGAP (which we name CrfRabGAP) that is found in the flagellar proteome of the unicellular green alga Chlamydomonas reinhardtii. BLAST searches revealed potential human orthologues of CrfRabGAP as TBC1D3 and TBC1D26. Sequence and structural comparison with other canonical RabGAPs revealed that the CrfRabGAP does not contain the canonical catalytic residues required for the activation of Rab GTPases. The function of noncanonical RabGAPs-like CrfRabGAP might be to serve as Rab effectors rather than activators.Proteins 2014;. (c) 2014 Wiley Periodicals, Inc.

Crystal structure of a Chlamydomonas reinhardtii flagellar RabGAP TBC-domain at 1.8 A resolution.,Bhogaraju S, Lorentzen E Proteins. 2014 May 9. doi: 10.1002/prot.24597. PMID:24810373<ref>PMID:24810373</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 4p17" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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[[Category: Chlamydomonas reinhardtii]]
[[Category: Large Structures]]
[[Category: Bhogaraju S]]
[[Category: Lorentzen E]]