View source for 4qyk


==Crystal structure of a canine parvovirus variant==
<StructureSection load='4qyk' size='340' side='right'caption='[[4qyk]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4qyk]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Feline_panleukopenia_virus Feline panleukopenia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QYK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qyk OCA], [https://pdbe.org/4qyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qyk RCSB], [https://www.ebi.ac.uk/pdbsum/4qyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qyk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P90456_FPV P90456_FPV] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Canine parvovirus (CPV-2) emerged in 1978 and spread worldwide within two years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.

Global displacement of canine parvovirus by a host-adapted variant: A structural comparison between pandemic viruses with distinct host ranges.,Organtini LJ, Allison AB, Lukk T, Parrish CR, Hafenstein S J Virol. 2014 Nov 19. pii: JVI.02611-14. PMID:25410876<ref>PMID:25410876</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4qyk" style="background-color:#fffaf0;"></div>

==See Also==
*[[Canine parvovirus|Canine parvovirus]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Feline panleukopenia virus]]
[[Category: Large Structures]]
[[Category: Hafenstein SU]]
[[Category: Lukk T]]
[[Category: Organtini LJ]]