View source for 4wfv


==Bovine allergen Bos d 2 in the monoclinic space group C2.==
<StructureSection load='4wfv' size='340' side='right'caption='[[4wfv]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4wfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WFV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wfv OCA], [https://pdbe.org/4wfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wfv RCSB], [https://www.ebi.ac.uk/pdbsum/4wfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wfv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALL2_BOVIN ALL2_BOVIN] Probable pheromone carrier.
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== Publication Abstract from PubMed ==
Lipocalins are one of the most important groups of inhalant animal allergens. The analysis of structural features of these proteins is important to get insights into their allergenicity. We have determined two different dimeric crystal structures for bovine dander lipocalin Bos d 2, which was earlier described as a monomeric allergen. The crystal structure analysis of all other determined lipocalin allergens also revealed oligomeric structures which broadly utilize inherent structural features of the beta-sheet in dimer formation. According to the moderate size of monomer-monomer interfaces, most of these dimers would be transient in solution. Native mass spectrometry was employed to characterize quantitatively transient dimerization of two lipocalin allergens, Bos d 2 and Bos d 5, in solution.

Dimerization of lipocalin allergens.,Niemi MH, Rytkonen-Nissinen M, Miettinen I, Janis J, Virtanen T, Rouvinen J Sci Rep. 2015 Sep 8;5:13841. doi: 10.1038/srep13841. PMID:26346541<ref>PMID:26346541</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4wfv" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Niemi MH]]
[[Category: Rouvinen J]]