View source for 5jcv


==Sortase B from Listeria monocytogenes.==
<StructureSection load='5jcv' size='340' side='right'caption='[[5jcv]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jcv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JCV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jcv OCA], [https://pdbe.org/5jcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jcv RCSB], [https://www.ebi.ac.uk/pdbsum/5jcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jcv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRTB_LISMO SRTB_LISMO] Transpeptidase that anchors surface proteins to the cell wall (Probable) (PubMed:16247833, PubMed:19129190). Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable). Catalyzes a cell wall sorting reaction in which a surface protein with the consensus sorting signal NP(Q/K)(T/S)(N/G/S)(D/A) is cleaved between the fourth and fifth residues, and the fourth position is linked to the cell wall (Probable) (PubMed:19129190). This is not the major sortase in Listeria, it seems to anchor only 2 proteins, Hbp2 (SvpA) and Hbp1 (PubMed:15028680, PubMed:16247833).<ref>PMID:15028680</ref> <ref>PMID:16247833</ref> <ref>PMID:19129190</ref> <ref>PMID:15028680</ref> <ref>PMID:16247833</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Listeria monocytogenes EGD-e]]
[[Category: Anderson WF]]
[[Category: Grimshaw S]]
[[Category: Joachimiak A]]
[[Category: Osipiuk J]]
[[Category: Zhou M]]