View source for 8cpg


==Structure of the AT-Hook 1 peptide from the mammalian HMGA protein in complex with DNA==
<StructureSection load='8cpg' size='340' side='right'caption='[[8cpg]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8cpg]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CPG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cpg OCA], [https://pdbe.org/8cpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cpg RCSB], [https://www.ebi.ac.uk/pdbsum/8cpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cpg ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HMGA1_HUMAN HMGA1_HUMAN] A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.
== Function ==
[https://www.uniprot.org/uniprot/HMGA1_HUMAN HMGA1_HUMAN] HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Boer DR]]
[[Category: Campos JL]]