View source for 8sta


==Isobutyryl-CoA mutase fused in the presence of GMPPCP==
<StructureSection load='8sta' size='340' side='right'caption='[[8sta]], [[Resolution|resolution]] 7.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8sta]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_metallidurans_CH34 Cupriavidus metallidurans CH34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8STA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8STA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sta OCA], [https://pdbe.org/8sta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sta RCSB], [https://www.ebi.ac.uk/pdbsum/8sta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sta ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ICMF_CUPMC ICMF_CUPMC] Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, and to a much lesser extent, of pivalyl-CoA and isovaleryl-CoA, using radical chemistry (PubMed:22167181). Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly (PubMed:22167181, PubMed:25675500). The G-domain of IcmF has also a role in its cofactor repair (PubMed:28130442). Does not display ATPase activity.<ref>PMID:22167181</ref> <ref>PMID:25675500</ref> <ref>PMID:28130442</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Cupriavidus metallidurans CH34]]
[[Category: Large Structures]]
[[Category: Drennan CL]]
[[Category: Vaccaro FA]]