View source for 8tbq


==The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody==
<StructureSection load='8tbq' size='340' side='right'caption='[[8tbq]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tbq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TBQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.593&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tbq OCA], [https://pdbe.org/8tbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tbq RCSB], [https://www.ebi.ac.uk/pdbsum/8tbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tbq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VISTA_HUMAN VISTA_HUMAN] Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).[UniProtKB:Q9D659]<ref>PMID:20666777</ref> <ref>PMID:24691993</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mukherjee A]]
[[Category: Thisted T]]
[[Category: Van der Horst EH]]