View source for 8ztb


==Crystal Structure of Active Site Influencing Variant (F218Y) of Imp-1 Metallo-beta-lactamase.==
<StructureSection load='8ztb' size='340' side='right'caption='[[8ztb]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ztb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZTB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ztb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ztb OCA], [https://pdbe.org/8ztb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ztb RCSB], [https://www.ebi.ac.uk/pdbsum/8ztb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ztb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLBI1_SERMA BLBI1_SERMA] Class B beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, cephalosporins and carbapenems (PubMed:10898670, PubMed:29485857, PubMed:8141584). Acts via hydrolysis of the beta-lactam ring (PubMed:10898670, PubMed:15788415). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities (PubMed:10898670, PubMed:15788415, PubMed:15892033). Has endoribonuclease activity, cleaving substrate RNAs preferentially between U/C and A, in vitro (PubMed:33126240).<ref>PMID:10898670</ref> <ref>PMID:15788415</ref> <ref>PMID:15892033</ref> <ref>PMID:29485857</ref> <ref>PMID:33126240</ref> <ref>PMID:8141584</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Serratia marcescens]]
[[Category: Baidya S]]
[[Category: Dhankhar K]]
[[Category: Hazra S]]