View source for 9dcp


==Structure of PmHMGR bound to mevalonate, CoA and NAD 1 minute after reaction initiation at pH 9==
<StructureSection load='9dcp' size='340' side='right'caption='[[9dcp]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9dcp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DCP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AFY:(3~{R})-3-methyl-3-oxidanyl-5-oxidanylidene-pentanoic+acid'>A1AFY</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MEV:(R)-MEVALONATE'>MEV</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dcp OCA], [https://pdbe.org/9dcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dcp RCSB], [https://www.ebi.ac.uk/pdbsum/9dcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dcp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas mevalonii]]
[[Category: Purohit V]]
[[Category: Stauffacher CV]]