View source for 9unm


==native NMDA receptor-GluN1/N2A-S2 in the closed state==
<StructureSection load='9unm' size='340' side='right'caption='[[9unm]], [[Resolution|resolution]] 6.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9unm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UNM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.37&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JC9:(2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one'>JC9</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9unm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9unm OCA], [https://pdbe.org/9unm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9unm RCSB], [https://www.ebi.ac.uk/pdbsum/9unm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9unm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NMDZ1_MOUSE NMDZ1_MOUSE] Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:12008020, PubMed:12860921, PubMed:14602821, PubMed:1532151, PubMed:8060614, PubMed:9049108). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:12008020, PubMed:1532151, PubMed:7790891, PubMed:8060614). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (PubMed:12860921). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:12008020, PubMed:14602821).[UniProtKB:Q05586]<ref>PMID:12008020</ref> <ref>PMID:12860921</ref> <ref>PMID:14602821</ref> <ref>PMID:1532151</ref> <ref>PMID:7790891</ref> <ref>PMID:8060614</ref> <ref>PMID:9049108</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ge JP]]
[[Category: Xu RS]]
[[Category: Yu J]]