View source for 9xqu


==ZnT10 tetramer with zinc==
<StructureSection load='9xqu' size='340' side='right'caption='[[9xqu]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9xqu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XQU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xqu OCA], [https://pdbe.org/9xqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xqu RCSB], [https://www.ebi.ac.uk/pdbsum/9xqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xqu ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ZNT10_HUMAN ZNT10_HUMAN] Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ZNT10_HUMAN ZNT10_HUMAN] Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:26728129, PubMed:27226609, PubMed:27307044). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129).<ref>PMID:22341972</ref> <ref>PMID:22427991</ref> <ref>PMID:25319704</ref> <ref>PMID:26728129</ref> <ref>PMID:27226609</ref> <ref>PMID:27307044</ref> <ref>PMID:30755481</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chi X]]
[[Category: Feng R]]
[[Category: Mu H]]
[[Category: Song D]]
[[Category: Wang Y]]
[[Category: Yang C]]
[[Category: Yu H]]