View source for 3vsx

{{STRUCTURE_3vsx|  PDB=3vsx  |  SCENE=  }} 
===Human renin in complex with compound 18===
{{ABSTRACT_PUBMED_22726934}}

==Disease==
[[http://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[http://omim.org/entry/267430 267430]]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref>  Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[http://omim.org/entry/613092 613092]]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref> 

==Function==
[[http://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN]] Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. 

==About this Structure==
[[3vsx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VSX OCA]. 

==See Also==
*[[Renin|Renin]]

==Reference==
<ref group="xtra">PMID:022726934</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Renin]]
[[Category: Hanzawa, H.]]
[[Category: Takahashi, M.]]
[[Category: Aspartyl protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hypertension]]
[[Category: Inhibitor]]
[[Category: Ra]]