View source for 4lek

{{STRUCTURE_4lek|  PDB=4lek  |  SCENE=  }} 
===Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines===
{{ABSTRACT_PUBMED_24428639}}

==Function==
[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. 

==About this Structure==
[[4lek]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEK OCA]. 

==Reference==
<ref group="xtra">PMID:024428639</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Hilgers, M T.]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]