View source for 4bfm

{{STRUCTURE_4bfm|  PDB=4bfm  |  SCENE=  }} 
===The crystal structure of mouse PK38===
{{ABSTRACT_PUBMED_24531485}}

==Function==
[[http://www.uniprot.org/uniprot/MELK_MOUSE MELK_MOUSE]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:16061694</ref> <ref>PMID:18948261</ref>  

==About this Structure==
[[4bfm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFM OCA]. 

==Reference==
<ref group="xtra">PMID:024531485</ref><references group="xtra"/><references/>
[[Category: Cho, H S.]]
[[Category: Cho, Y S.]]
[[Category: Park, S M.]]
[[Category: Yoo, J H.]]
[[Category: Transferase]]