View source for 2ewa

[[Image:2ewa.gif|left|200px]]

 {{Structure
|PDB= 2ewa |SIZE=350|CAPTION= <scene name='initialview01'>2ewa</scene>, resolution 2.1&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=SB2:4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE'>SB2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] 
|GENE= Mapk14, Crk1, Csbp1, Csbp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
}}

'''Dual binding mode of pyridinylimidazole to MAP kinase p38'''


==About this Structure==
2EWA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EWA OCA]. 

==Reference==
NMR characterization of kinase p38 dynamics in free and ligand-bound forms., Vogtherr M, Saxena K, Hoelder S, Grimme S, Betz M, Schieborr U, Pescatore B, Robin M, Delarbre L, Langer T, Wendt KU, Schwalbe H, Angew Chem Int Ed Engl. 2006 Jan 30;45(6):993-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16374788 16374788]
[[Category: Mus musculus]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Single protein]]
[[Category: Delarbre, L.]]
[[Category: Guilloteau, J P.]]
[[Category: Michot, N.]]
[[Category: Pouzieux, S.]]
[[Category: SB2]]
[[Category: dfg out]]
[[Category: map kinase]]

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