View source for 2mnb

==Thiazotropsin B DNA recognition sequence d(CGACGCGTCG)2==
<StructureSection load='2mnb' size='340' side='right' caption='[[2mnb]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mnb]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MNB FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mnb RCSB], [http://www.ebi.ac.uk/pdbsum/2mnb PDBsum]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Solution-phase self-association characteristics and DNA molecular-recognition properties are reported for three close analogues of minor-groove-binding ligands from the thiazotropsin class of lexitropsin molecules; they incorporate isopropyl thiazole as a lipophilic building block. Thiazotropsin B (AcImPyiPr ThDp) shows similar self-assembly characteristics to thiazotropsin A (FoPyPyiPr ThDp), although it is engineered, by incorporation of imidazole in place of N-methyl pyrrole, to swap its DNA recognition target from 5'-ACTAGT-3' to 5'-ACGCGT-3'. Replacement of the formamide head group in thiazotropsin A by nicotinamide in AIK-18/51 results in a measureable difference in solution-phase self-assembly character and substantially enhanced DNA association characteristics. The structures and associated thermodynamic parameters of self-assembled ligand aggregates and their complexes with their respective DNA targets are considered in the context of cluster targeting of DNA by minor-groove complexes.

Recognition of the DNA Minor Groove by Thiazotropsin Analogues.,Alniss HY, Salvia MV, Sadikov M, Golovchenko I, Anthony NG, Khalaf AI, MacKay SP, Suckling CJ, Parkinson JA Chembiochem. 2014 Jul 16. doi: 10.1002/cbic.201402202. PMID:25045155<ref>PMID:25045155</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Alniss, H Y]]
[[Category: Anthony, N G]]
[[Category: Golovchenko, I]]
[[Category: Khalaf, A I]]
[[Category: Mackay, S P]]
[[Category: Parkinson, J A]]
[[Category: Sadikov, M]]
[[Category: Salvia, M V]]
[[Category: Suckling, C J]]
[[Category: Dna]]
[[Category: Dna recognition]]
[[Category: Isothermal titration calorimetry nmr]]
[[Category: Minor groove binder]]
[[Category: Self-assembly]]
[[Category: Thiazotropsin]]