View source for 2pm9

[[Image:2pm9.jpg|left|200px]]

 {{Structure
|PDB= 2pm9 |SIZE=350|CAPTION= <scene name='initialview01'>2pm9</scene>, resolution 3.300&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= WEB1, SEC31 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SEC13, ANU3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
}}

'''Crystal structure of yeast Sec13/31 vertex element of the COPII vesicular coat'''


==Overview==
COPII-coated vesicles export newly synthesized proteins from the endoplasmic reticulum. The COPII coat consists of the Sec23/24-Sar1 complex that selects cargo and the Sec13/31 assembly unit that can polymerize into an octahedral cage and deform the membrane into a bud. Crystallographic analysis of the assembly unit reveals a 28 nm long rod comprising a central alpha-solenoid dimer capped by two beta-propeller domains at each end. We construct a molecular model of the COPII cage by fitting Sec13/31 crystal structures into a recently determined electron microscopy density map. The vertex geometry involves four copies of the Sec31 beta-propeller that converge through their axial ends; there is no interdigitation of assembly units of the kind seen in clathrin cages. We also propose that the assembly unit has a central hinge-an arrangement of interlocked alpha-solenoids-about which it can bend to adapt to cages of variable curvature.

==About this Structure==
2PM9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PM9 OCA]. 

==Reference==
Structure and organization of coat proteins in the COPII cage., Fath S, Mancias JD, Bi X, Goldberg J, Cell. 2007 Jun 29;129(7):1325-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17604721 17604721]
[[Category: Protein complex]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Bi, X.]]
[[Category: Fath, S.]]
[[Category: Goldberg, J.]]
[[Category: Mancias, J D.]]
[[Category: beta propeller]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:14:46 2008''