View source for 2trc

[[Image:2trc.gif|left|200px]]

 {{Structure
|PDB= 2trc |SIZE=350|CAPTION= <scene name='initialview01'>2trc</scene>, resolution 2.4&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=GD:GADOLINIUM ATOM'>GD</scene>
|ACTIVITY= 
|GENE= 
}}

'''PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX'''


==Overview==
The crystal structure of transducin's betagamma subunits complexed with phosducin, which regulates Gtbetagamma activity, has been solved to 2.4 angstroms resolution. Phosducin has two domains that wrap around Gtbetagamma to form an extensive interface. The N-terminal domain binds loops on the "top" Gtbeta surface, overlapping the Gtalpha binding surface, explaining how phosducin blocks Gtbetagamma's interaction with Gtalpha. The C-terminal domain shows structural homology to thioredoxin and binds the outer strands of Gtbeta's seventh and first blades in a manner likely to disrupt Gtbetagamma's normal orientation relative to the membrane and receptor. Phosducin's Ser-73, which when phosphorylated inhibits phosducin's function, points away from Gtbetagamma, toward a large flexible loop. Thus phosphorylation is not likely to affect the interface directly, but rather indirectly through an induced conformational change.

==About this Structure==
2TRC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TRC OCA]. 

==Reference==
Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin., Gaudet R, Bohm A, Sigler PB, Cell. 1996 Nov 1;87(3):577-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8898209 8898209]
[[Category: Bos taurus]]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Bohm, A.]]
[[Category: Gaudet, R.]]
[[Category: Sigler, P B.]]
[[Category: GD]]
[[Category: beta-gamma]]
[[Category: complex (transducer/transduction)]]
[[Category: g protein]]
[[Category: meka]]
[[Category: phosducin]]
[[Category: phosphorylation]]
[[Category: regulation]]
[[Category: signal transduction]]
[[Category: thioredoxin]]
[[Category: transducin]]
[[Category: vision]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:39:22 2008''