View source for 9pai

[[Image:9pai.gif|left|200px]]

 {{Structure
|PDB= 9pai |SIZE=350|CAPTION= <scene name='initialview01'>9pai</scene>, resolution 2.7&Aring;
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
}}

'''CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1'''


==Overview==
Plasminogen activator inhibitor-1 (PAI-1) is unique among the serine proteinase inhibitors (serpins) in that it can adopt at least three different conformations (active, substrate and latent). We report the X-ray structure of a cleaved substrate variant of human PAI-1, which has a new beta-strand s4A formed by insertion of the amino-terminal portion of the reactive-site loop into beta-sheet A subsequent to cleavage. This is in contrast to the previous suggestion that the non-inhibitory function of substrate-type serpins is mainly due to an inability of the reactive-site loop to adopt this conformation. Comparison with the structure of latent PAI-1 provides insights into the molecular determinants responsible for the transition of the stressed active conformation to the thermostable latent conformation.

==Disease==
Known diseases associated with this structure: Hemorrhagic diathesis due to PAI1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173360 173360]], Thrombophilia due to excessive plasminogen activator inhibitor OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173360 173360]]

==About this Structure==
9PAI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PAI OCA]. 

==Reference==
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1., Aertgeerts K, De Bondt HL, De Ranter CJ, Declerck PJ, Nat Struct Biol. 1995 Oct;2(10):891-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7552714 7552714]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Aertgeerts, K.]]
[[Category: Bondt, H L.De.]]
[[Category: Declerck, P J.]]
[[Category: Ranter, C J.De.]]
[[Category: serpin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:16:41 2008''