View source for 2ea5

==Solution Structure of the RING domain of the human Cell growth regulator with RING finger domain 1 protein==
<StructureSection load='2ea5' size='340' side='right' caption='[[2ea5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ea5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EA5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CGRRF1, CGR19, RNF197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ea5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ea5 OCA], [http://pdbe.org/2ea5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ea5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ea5 PDBsum], [http://www.topsan.org/Proteins/RSGI/2ea5 TOPSAN]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CGRF1_HUMAN CGRF1_HUMAN]] Able to inhibit growth in several cell lines (By similarity). 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2ea5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Harada, T]]
[[Category: Kigawa, T]]
[[Category: Koshiba, S]]
[[Category: Miyamoto, K]]
[[Category: Structural genomic]]
[[Category: Tomizawa, T]]
[[Category: Watanabe, S]]
[[Category: Yokoyama, S]]
[[Category: Cell cycle]]
[[Category: Cell growth regulator with ring finger domain 1]]
[[Category: Cgrrf1]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Ring domain]]
[[Category: Rsgi]]
[[Category: Zinc-binding domain]]