View source for 377d


==5'-R(*CP*GP*UP*AP*CP*DG)-3'==
<StructureSection load='377d' size='340' side='right' caption='[[377d]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[377d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=377D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=377D FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=377d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=377d OCA], [http://pdbe.org/377d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=377d RCSB], [http://www.ebi.ac.uk/pdbsum/377d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=377d ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the alternating RNA r(CGUAC)dG with a 3'-terminal deoxy G residue has been determined at 1.76 A resolution. The crystal belongs to the orthorhombic space group C2221, unit-cell dimensions a = 29.53, b = 44.61 and c = 94.18 A, with two independent duplexes (I and II) per asymmetric unit. The structure was solved by the molecular-replacement method. The final R factor was 18.8% using 4757 reflections in the resolution range 8.0-1.76 A. The model contains a total of 496 atoms and 85 solvent molecules. The two duplexes form the repeating unit and stack in the usual head-to-tail (5',3'/5',3') fashion into a pseudocontinuous helical column. Almost all of the 2'-hydroxyl groups are engaged in the three modes of water-mediated interactions to the base N3/O2 atoms, the sugar O4' atoms and the backbone phosphates. Thus, the 2'-hydroxyl group of RNA is probably contributing to the stability of the duplexes.

1.76 A structure of a pyrimidine start alternating A-RNA hexamer r(CGUAC)dG.,Biswas R, Mitra SN, Sundaralingam M Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):570-6. PMID:9761851<ref>PMID:9761851</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 377d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Biswas, R]]
[[Category: Mitra, S N]]
[[Category: Sundaralingam, M]]
[[Category: A-rna]]
[[Category: Double helix]]
[[Category: Rna]]