View source for 3uke


==(S)-cMOE-BNA decamer structure==
<StructureSection load='3uke' size='340' side='right' caption='[[3uke]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uke]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UKE FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSM:1-{2,5-ANHYDRO-6-O-METHYL-4-[(PHOSPHONOOXY)METHYL]-ALPHA-L-MANNOFURANOSYL}PYRIMIDINE-2,4(1H,3H)-DIONE'>CSM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ukb|3ukb]], [[3ukc|3ukc]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uke OCA], [http://pdbe.org/3uke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uke RCSB], [http://www.ebi.ac.uk/pdbsum/3uke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uke ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.

Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.,Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M Chem Commun (Camb). 2012 May 22. PMID:22614180<ref>PMID:22614180</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3uke" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Egli, M]]
[[Category: Pallan, P S]]
[[Category: A-form dna]]
[[Category: Antisense oligonucleotide]]
[[Category: Bicyclic nucleic acid]]
[[Category: Bna]]
[[Category: C-moe-bna]]
[[Category: Dna]]