View source for 2dlr


==Solution structure of the RGS domain of human Regulator of G-protein signaling 10==
<StructureSection load='2dlr' size='340' side='right' caption='[[2dlr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dlr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DLR FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlr OCA], [http://pdbe.org/2dlr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dlr RCSB], [http://www.ebi.ac.uk/pdbsum/2dlr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlr ProSAT], [http://www.topsan.org/Proteins/RSGI/2dlr TOPSAN]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RGS10_HUMAN RGS10_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dlr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dlr ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Regulator of G protein signaling|Regulator of G protein signaling]]
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Hayashi, F]]
[[Category: Nagashima, T]]
[[Category: Structural genomic]]
[[Category: Yokoyama, S]]
[[Category: Zhang, H P]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Regulator of g-protein signaling 10]]
[[Category: Rgs domain]]
[[Category: Rgs10]]
[[Category: Rsgi]]
[[Category: Signaling protein]]