View source for 2phf

[[Image:2phf.jpg|left|200px]]

 {{Structure
|PDB= 2phf |SIZE=350|CAPTION= <scene name='initialview01'>2phf</scene>, resolution 2.1&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=[[1q8p|1Q8P]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2phf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2phf OCA], [http://www.ebi.ac.uk/pdbsum/2phf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2phf RCSB]</span>
}}

'''Pterocarpus angolensis lectin complexed with Man-6'''


==Overview==
The crystal structure of Pterocarpus angolensis seed lectin is presented in complex with a series of high mannose (Man) oligosaccharides ranging from Man-5 to Man-9. Despite that several of the nine Man residues of Man-9 have the potential to bind in the monosaccharide-binding site, all oligomannoses are bound in the same unique way, employing the tetrasaccharide sequence Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-. Isothermal titration calorimetry titration experiments using Man-5, Man-9, and the Man-9-containing glycoprotein soybean (Glycine max) agglutinin as ligands confirm the monovalence of Man-9 and show a 4-times higher affinity for Man-9 when it is presented to P. angolensis seed lectin in a glycoprotein context.

==About this Structure==
2PHF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PHF OCA]. 

==Reference==
How a plant lectin recognizes high mannose oligosaccharides., Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R, Plant Physiol. 2007 Aug;144(4):1733-41. Epub 2007 Jun 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17556509 17556509]
[[Category: Pterocarpus angolensis]]
[[Category: Single protein]]
[[Category: Buts, L.]]
[[Category: Garcia-Pino, A.]]
[[Category: Imberty, A.]]
[[Category: Loris, R.]]
[[Category: Wyns, L.]]
[[Category: carbohydrate]]
[[Category: high mannose]]
[[Category: lectin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:35:54 2008''