View source for 4fps


==tRNA-Guanine Transglycosylase in complex with adamantyl-substituted lin-benzoguanine ligand==
<StructureSection load='4fps' size='340' side='right'caption='[[4fps]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fps]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymmo Zymmo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FPS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0UX:6-AMINO-2-(METHYLAMINO)-4-(2-{[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YLMETHYL]AMINO}ETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0UX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eos|3eos]], [[2z7k|2z7k]], [[3s1g|3s1g]], [[3v0y|3v0y]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tgt, ZMO0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 ZYMMO])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fps OCA], [http://pdbe.org/4fps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fps RCSB], [http://www.ebi.ac.uk/pdbsum/4fps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fps ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] 

==See Also==
*[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Zymmo]]
[[Category: Immekus, F]]
[[Category: Klebe, G]]
[[Category: Biosynthesis]]
[[Category: Glycosyltransferase]]
[[Category: Queuosine]]
[[Category: Tim barrel]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Trna]]
[[Category: Trna processing]]