View source for 7b60


==Crystal structure of MurE from E.coli in complex with Z1269139261==
<StructureSection load='7b60' size='340' side='right'caption='[[7b60]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7b60]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B60 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B60 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=O3D:4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione'>O3D</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.13 6.3.2.13] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b60 OCA], [http://pdbe.org/7b60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b60 RCSB], [http://www.ebi.ac.uk/pdbsum/7b60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b60 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI]] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Delft, F von]]
[[Category: Douangamath, A]]
[[Category: Edwards, A M]]
[[Category: Fairhead, M]]
[[Category: Koekemoer, L]]
[[Category: Krojer, T]]
[[Category: Structural genomic]]
[[Category: Steindel, M]]
[[Category: Talon, R]]
[[Category: 6-diaminopimelate ligase cell wall biosynthesis ligase]]
[[Category: Biosynthetic protein]]
[[Category: Drug target]]
[[Category: Fragment screening]]
[[Category: Sgc]]
[[Category: Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2]]