View source for 2xss


==Crystal structure of GAFb from the human phosphodiesterase 5==
<StructureSection load='2xss' size='340' side='right'caption='[[2xss]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2xss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSS FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xp0|1xp0]], [[1udt|1udt]], [[2h44|2h44]], [[1uho|1uho]], [[1t9s|1t9s]], [[1rkp|1rkp]], [[1udu|1udu]], [[2chm|2chm]], [[2h40|2h40]], [[1tbf|1tbf]], [[1t9r|1t9r]], [[2h42|2h42]], [[1xoz|1xoz]]</div></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xss OCA], [https://pdbe.org/2xss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xss RCSB], [https://www.ebi.ac.uk/pdbsum/2xss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xss ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. 

==See Also==
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
__TOC__
</StructureSection>
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Russwurm, M]]
[[Category: Schlicker, C]]
[[Category: Steegborn, C]]
[[Category: Hydrolase]]