View source for 1iox

[[Image:1iox.gif|left|200px]]<br />
<applet load="1iox" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1iox" />
'''NMR Structure of human Betacellulin-2'''<br />

==Overview==
The solution structure of the EGF-like domain of betacellulin (BTCe), a, newly discovered member of the epidermal growth factor (EGF) family, has, been determined using two-dimensional nuclear magnetic resonance, spectroscopy. This is the first report to identify the solution structure, of the EGF-family ligand monomers that interact with both ErbB-1 and, ErbB-4. The solution structure of BTCe was calculated using 538, NMR-derived restraints. The overall structure of BTCe was stabilized by, three disulfide bonds, a hydrophobic core, and 23 hydrogen bonds. It, appears that BTCe is comprised of five beta-strands and one short 3(10), helical turn. The secondary structural elements of BTCe are basically, similar to those of the other EGF-family proteins, except that several, significant variations of the structural properties were found. It is, suggested that the structural variations between BTCe and the other, EGF-family ligands may affect the specific receptor-recognition properties, of EGF-family ligands.

==About this Structure==
1IOX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IOX OCA]. 

==Reference==
Solution structure of betacellulin, a new member of EGF-family ligands., Miura K, Doura H, Aizawa T, Tada H, Seno M, Yamada H, Kawano K, Biochem Biophys Res Commun. 2002 Jun 28;294(5):1040-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12074582 12074582]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Aizawa, T.]]
[[Category: Doura, H.]]
[[Category: Kawano, K.]]
[[Category: Miura, K.]]
[[Category: Seno, M.]]
[[Category: Tada, H.]]
[[Category: Yamada, H.]]
[[Category: egf-like fold]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:32:41 2007''