View source for 1ubd

[[Image:1ubd.gif|left|200px]]<br />
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caption="1ubd, resolution 2.500&Aring;" />
'''CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT'''<br />

==Overview==
Ying-Yang 1 protein (YY1) supports specific, unidirectional initiation of, messenger RNA production by RNA polymerase II from two adjacent start, sites in the adeno-associated virus P5 promoter, a process which is, independent of the TATA box-binding protein (TBP). The 2.5-A resolution, YY1-initiator element cocrystal structure reveals four zinc fingers, recognizing a YY1-binding consensus sequence. Upstream of the, transcription start sites protein-DNA contacts involve both strands and, downstream they are virtually restricted to the template strand, permitting access to the active center of RNA polymerase II and ensuring, specificity and directionality. The observed pattern of protein-DNA, contacts also explains YY1 binding to a preformed transcription bubble, and YY1 binding to a DNA/RNA hybrid analog of the P5 promoter region, containing a nascent RNA transcript. A model is proposed for YY1-directed, TBP-independent transcription initiation.

==About this Structure==
1UBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UBD OCA]. 

==Reference==
Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator., Houbaviy HB, Usheva A, Shenk T, Burley SK, Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13577-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8942976 8942976]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Burley, S.K.]]
[[Category: Houbaviy, H.B.]]
[[Category: Shenk, T.]]
[[Category: Usheva, A.]]
[[Category: ZN]]
[[Category: complex (transcription regulation/dna)]]
[[Category: dna- protein recognition]]
[[Category: initiator element]]
[[Category: transcription initiation]]
[[Category: yy1]]
[[Category: zinc finger protein]]

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