View source for 2cab

[[Image:2cab.gif|left|200px]]<br />
<applet load="2cab" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2cab, resolution 2.0&Aring;" />
'''STRUCTURE, REFINEMENT AND FUNCTION OF CARBONIC ANHYDRASE ISOZYMES. REFINEMENT OF HUMAN CARBONIC ANHYDRASE I'''<br />

==Overview==
The structure of human erythrocyte carbonic anhydrase I has been refined, to a final R value of 19% to 2-A resolution by a combination of least, squares refinement and model fitting in a three-dimensional graphics, display. About 300 solvent atoms have been located bound to the protein, molecule. An interesting hydrogen bond network involving Zn2+, the, liganded solvent, side chain groups of Thr-199, Glu-106, Thr-7, and His-64, through two solvent molecules have been found that may be important for, the catalytic mechanism of the carbonic anhydrase.

==About this Structure==
2CAB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. This structure superseeds the now removed PDB entry 1CAB. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CAB OCA]. 

==Reference==
Structure, refinement, and function of carbonic anhydrase isozymes: refinement of human carbonic anhydrase I., Kannan KK, Ramanadham M, Jones TA, Ann N Y Acad Sci. 1984;429:49-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=6430186 6430186]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Jones, T.A.]]
[[Category: Kannan, K.K.]]
[[Category: Ramanadham, M.]]
[[Category: ZN]]
[[Category: hydro-lyase]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:13:20 2007''