View source for 2hrv

[[Image:2hrv.jpg|left|200px]]

<!--
The line below this paragraph, containing "STRUCTURE_2hrv", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet) 
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_2hrv|  PDB=2hrv  |  SCENE=  }} 

'''2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2'''


==Overview==
The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2-2A(pro)) has been solved to 1.95 A resolution. The structure has an unusual, although chymotrypsin-related, fold comprising a unique four-stranded beta sheet as the N-terminal domain and a six-stranded beta barrel as the C-terminal domain. A tightly bound zinc ion, essential for the stability of HRV2-2A(pro), is tetrahedrally coordinated by three cysteine sulfurs and one histidine nitrogen. The active site consists of a catalytic triad formed by His18, Asp35 and Cys106. Asp35 is additionally involved in an extensive hydrogen-bonding network. Modelling studies reveal a substrate-induced fit that explains the specificity of the subsites S4, S2, S1 and S1'. The structure of HRV2-2A(pro) suggests the mechanism of the cis cleavage and its release from the polyprotein.

==About this Structure==
2HRV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_2 Human rhinovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRV OCA]. 

==Reference==
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis., Petersen JF, Cherney MM, Liebig HD, Skern T, Kuechler E, James MN, EMBO J. 1999 Oct 15;18(20):5463-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10523291 10523291]
[[Category: Human rhinovirus 2]]
[[Category: Picornain 2A]]
[[Category: Single protein]]
[[Category: Cherney, M M.]]
[[Category: James, M N.G.]]
[[Category: Kuechler, E.]]
[[Category: Liebig, H D.]]
[[Category: Petersen, J F.W.]]
[[Category: Skern, T.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:38:20 2008''