View source for 1msf

[[Image:1msf.jpg|left|200px]]<br /><applet load="1msf" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1msf" />
'''SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES'''<br />

==Overview==
The DNA-binding region of Myb consists of three imperfect tandem repeats, (R1, R2, and R3). We have determined the solution structure of a specific, DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear, multidimensional NMR. Both R2 and R3 contain three helices, and the third, helix in each is found to be a recognition helix. R2 and R3 are closely, packed in the major groove, so that the two recognition helices contact, each other directly to bind to the specific base sequence, AACNG, cooperatively; this is a significant arrangement of recognition helices., The three key base pairs in this sequence are specifically recognized by, Asn-183 (R3), Lys-182 (R3), and Lys-128 (R2). In contrast, R1 has no, specific interactions with DNA from our NMR study of the DNA complex of, the full DNA-binding domain (R1R2R3).

==About this Structure==
1MSF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MSF OCA]. 

==Reference==
Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices., Ogata K, Morikawa S, Nakamura H, Sekikawa A, Inoue T, Kanai H, Sarai A, Ishii S, Nishimura Y, Cell. 1994 Nov 18;79(4):639-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7954830 7954830]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Inoue, T.]]
[[Category: Ishii, S.]]
[[Category: Kanai, H.]]
[[Category: Morikawa, S.]]
[[Category: Nakamura, H.]]
[[Category: Nishimura, Y.]]
[[Category: Ogata, K.]]
[[Category: Sarai, A.]]
[[Category: Sekikawa, A.]]
[[Category: dna binding protein/dna]]

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