View source for 2bvb

[[Image:2bvb.gif|left|200px]]<br /><applet load="2bvb" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2bvb" />
'''THE C-TERMINAL DOMAIN FROM MICRONEMAL PROTEIN 1 (MIC1) FROM TOXOPLASMA GONDII'''<br />

==Overview==
Immediately prior to invasion Toxoplasma gondii tachyzoites release a, large number of micronemal proteins (TgMICs) that participate in host cell, attachment and penetration. The TgMIC4-MIC1-MIC6 complex was the first to, be identified in T. gondii and has been recently shown to be critical in, invasion. This study establishes that the N-terminal thrombospondin type I, repeat-like domains (TSR1-like) from TgMIC1 function as an independent, adhesin as well as promoting association with TgMIC4. Using the newly, solved three-dimensional structure of the C-terminal domain of TgMIC1 we, have identified a novel Galectin-like fold that does not possess, carbohydrate binding properties and redefines the architecture of TgMIC1., Instead, the TgMIC1 Galectin-like domain interacts and stabilizes TgMIC6, which provides the basis for a highly specific quality control mechanism, for successful exit from the early secretory compartments and for, subsequent trafficking of the complex to the micronemes.

==About this Structure==
2BVB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BVB OCA]. 

==Reference==
A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex., Saouros S, Edwards-Jones B, Reiss M, Sawmynaden K, Cota E, Simpson P, Dowse TJ, Jakle U, Ramboarina S, Shivarattan T, Matthews S, Soldati-Favre D, J Biol Chem. 2005 Nov 18;280(46):38583-91. Epub 2005 Sep 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16166092 16166092]
[[Category: Single protein]]
[[Category: Toxoplasma gondii]]
[[Category: Cota, E.]]
[[Category: Dowse, T.]]
[[Category: Edwards-Jones, B.]]
[[Category: Jakle, U.]]
[[Category: Matthews, S.]]
[[Category: Ramboarina, S.]]
[[Category: Reiss, M.]]
[[Category: Saouros, S.]]
[[Category: Sawmynaden, K.]]
[[Category: Shivarattan, T.]]
[[Category: Simpson, P.]]
[[Category: Soldati-Favre, D.]]
[[Category: adhesion]]
[[Category: invasion]]
[[Category: mic1]]
[[Category: microneme]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:56:01 2007''