View source for 2brv

[[Image:2brv.gif|left|200px]]<br />
<applet load="2brv" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2brv, resolution 3.30&Aring;" />
'''CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE FROM 70PERCENT SATURATED MALONATE.'''<br />

==Overview==
Streptococcus pneumoniae hyaluronan lyase is a surface enzyme of this, Gram-positive bacterium. The enzyme degrades several biologically, important, information-rich linear polymeric glycans: hyaluronan, unsulfated chondroitin, and some chondroitin sulfates. This degradation, facilitates spreading of bacteria throughout the host tissues and, presumably provides energy and a carbon source for pneumococcal cells. Its, beta-elimination catalytic mechanism is an acid/base process termed proton, acceptance and donation leading to cleavage of beta-1,4 linkages of the, substrates. The degradation of hyaluronan occurs in two stages, initial, endolytic cuts are followed by processive exolytic cleavage of one, disaccharide at a time. In contrast, the degradation of chondroitins is, purely ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16569416 (full description)]]

==About this Structure==
2BRV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with MLA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BRV OCA]]. 

==Reference==
Alternate structural conformations of Streptococcus pneumoniae hyaluronan lyase: insights into enzyme flexibility and underlying molecular mechanism of action., Rigden DJ, Littlejohn JE, Joshi HV, de Groot BL, Jedrzejas MJ, J Mol Biol. 2006 May 12;358(4):1165-78. Epub 2006 Mar 13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16569416 16569416]
[[Category: Single protein]]
[[Category: Streptococcus pneumoniae]]
[[Category: Jedrzejas, M.J.]]
[[Category: Rigden, D.J.]]
[[Category: MLA]]
[[Category: (alfa5/alfa5) barrel]]
[[Category: cell wall]]
[[Category: lyase]]
[[Category: peptidoglycan-anchor]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:58:47 2007''