View source for 10ka


==Co-crystal Structure of CHI3L1 bound to DELC2 small molecule ligand==
<StructureSection load='10ka' size='340' side='right'caption='[[10ka]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[10ka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10KA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10KA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C9L:(3~{a}~{R},6~{a}~{R})-2-[(2~{R})-3-cyclopropyl-2-[(4-pyridin-2-ylphenyl)methylamino]propanoyl]-~{N}-[(2~{R})-1-(methylamino)-1-oxidanylidene-pentan-2-yl]-1,3,4,5,6,6~{a}-hexahydrocyclopenta[c]pyrrole-3~{a}-carboxamide'>A1C9L</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10ka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10ka OCA], [https://pdbe.org/10ka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10ka RCSB], [https://www.ebi.ac.uk/pdbsum/10ka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10ka ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
== Function ==
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gabr M]]
[[Category: Teplova M]]
[[Category: Upadhyay S]]
[[Category: Zhang L]]