View source for 10nh


==Crystal Structure of Apurinic endonuclease (APN1) from Babesia bovis==
<StructureSection load='10nh' size='340' side='right'caption='[[10nh]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[10nh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Babesia_bovis_T2Bo Babesia bovis T2Bo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10NH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10NH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10nh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10nh OCA], [https://pdbe.org/10nh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10nh RCSB], [https://www.ebi.ac.uk/pdbsum/10nh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10nh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S6B9Y3_BABBO S6B9Y3_BABBO] Plays a role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress. Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) with a preference for C as opposite base. Has 3'-phosphatase activity; removes 3'-phosphate from blunt-end, recessed, and gapped DNA templates and thus, removes 3'-blocks for DNA polymerase activity during BER. Lacks 3'-5' exonuclease activity and does not cleave damaged bases by nucleotide incision repair (NIR).[ARBA:ARBA00054483]
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</StructureSection>
[[Category: Babesia bovis T2Bo]]
[[Category: Large Structures]]