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==Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with benzoxaborole derivative of azithromycin (AZI-BB2), mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution==
<StructureSection load='10px' size='340' side='right'caption='[[10px]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[10px]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10PX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10PX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TD:(3S)-3-(METHYLSULFANYL)-L-ASPARTIC+ACID'>0TD</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=31H:3-DEOXY-3-[(N-FORMYL-L-METHIONYL)AMINO]ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>31H</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=4SU:4-THIOURIDINE-5-MONOPHOSPHATE'>4SU</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=A1C9N:(3aR,4R,7R,8S,9S,10R,11R,13R,16R,16aR)-8-{[(3xi)-2,6-dideoxy-4-O-({2-[3-(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanamido]ethyl}carbamoyl)-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl]oxy}-4-ethyl-11-hydroxy-3a,7,9,11,13,15,16-heptamethyl-2,6-dioxotetradecahydro-2H-[1,3]dioxolo[4,5-c][1,6]oxazacyclopentadecin-10-yl+3,4,6-trideoxy-3-(dimethylamino)-beta-D-ribo-hexopyranoside'>A1C9N</scene>, <scene name='pdbligand=F3N:3-DEOXY-3-(L-PHENYLALANYLAMINO)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>F3N</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=M2G:N2-DIMETHYLGUANOSINE-5-MONOPHOSPHATE'>M2G</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MIA:2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5-MONOPHOSPHATE'>MIA</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10px FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10px OCA], [https://pdbe.org/10px PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10px RCSB], [https://www.ebi.ac.uk/pdbsum/10px PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10px ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL31_THET8 RL31_THET8] Binds the 23S rRNA (By similarity).[HAMAP-Rule:MF_00501]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus HB8]]
[[Category: Bortyazh MO]]
[[Category: Chen C-W]]
[[Category: Dontsova OA]]
[[Category: Kabilov MR]]
[[Category: Karakchieva AO]]
[[Category: Komarova ES]]
[[Category: Lukianov DA]]
[[Category: Polikanov YS]]
[[Category: Sergiev PV]]
[[Category: Shchekotikhin AE]]
[[Category: Skvortsov DA]]
[[Category: Tashlitsky VN]]
[[Category: Tereshchenkov AG]]
[[Category: Tevyashova AN]]
[[Category: Tikhomirov AS]]
[[Category: Tupikin AE]]
[[Category: Volynkina IA]]