View source for 10xc


==Nocardia asteroides DnaA DI in the P4(1)22 space group==
<StructureSection load='10xc' size='340' side='right'caption='[[10xc]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[10xc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nocardia Nocardia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10XC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10XC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10xc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10xc OCA], [https://pdbe.org/10xc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10xc RCSB], [https://www.ebi.ac.uk/pdbsum/10xc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10xc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/U5EFM3_NOCAS U5EFM3_NOCAS] Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids.[HAMAP-Rule:MF_00377][RuleBase:RU000577]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Nocardia]]
[[Category: Ellis PK]]
[[Category: Schumacher MA]]