View source for 11iw


==Mouse monoclonal antibody A2 in complex with rabies virus glycoprotein==
<StructureSection load='11iw' size='340' side='right'caption='[[11iw]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[11iw]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11IW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11IW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11iw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11iw OCA], [https://pdbe.org/11iw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11iw RCSB], [https://www.ebi.ac.uk/pdbsum/11iw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11iw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLYCO_RABVP GLYCO_RABVP] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Rabies lyssavirus]]
[[Category: Bouhry H]]
[[Category: Callaway HM]]
[[Category: Corti D]]
[[Category: Dessain S]]
[[Category: Flynn A]]
[[Category: Hariharan C]]
[[Category: Harkins S]]
[[Category: Hastie K]]
[[Category: Kothalawalage S]]
[[Category: Samarasinghe S]]
[[Category: Saphire EO]]
[[Category: Yin J]]
[[Category: Zyla D]]