View source for 11lp


==Mouse monoclonal antibody A11 in complex with rabies virus glycoprotein==
<StructureSection load='11lp' size='340' side='right'caption='[[11lp]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[11lp]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11LP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11LP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.92&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11lp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11lp OCA], [https://pdbe.org/11lp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11lp RCSB], [https://www.ebi.ac.uk/pdbsum/11lp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11lp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLYCO_RABVP GLYCO_RABVP] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Rabies lyssavirus]]
[[Category: Bouhry H]]
[[Category: Callaway HM]]
[[Category: Corti D]]
[[Category: Dessain S]]
[[Category: Flynn A]]
[[Category: Hariharan C]]
[[Category: Harkins S]]
[[Category: Hastie K]]
[[Category: Kothalawalage S]]
[[Category: Samarasinghe S]]
[[Category: Saphire EO]]
[[Category: Yin J]]
[[Category: Zyla D]]